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Oct 17, 2024

Exploring the current development and applications of monoclonal antibodies

October 16, 2024 This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

October 16, 2024

This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

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by Sichuan International Medical Exchange and Promotion Association

A study led by Dr. Hassan Aboul-Ella (Department of Microbiology, Faculty of Veterinary Medicine, Cairo University) has been published in the journal Molecular Biomedicine.

The review provides comprehensive insights into the current fundamental landscape of monoclonal antibodies (mAbs) development and applications and the key factors influencing the future projections, advancement, and incorporation of such promising immunotherapeutic candidates as a confrontation approach against a wide list of diseases, with a rationalistic mentioning of any limitations facing this field.

mAbs are used to prevent, detect, and treat a broad spectrum of non-communicable and communicable diseases. Over the past few years, the market for mAbs has grown exponentially with an expected compound annual growth rate (CAGR) of 11.07% from 2024 (237.64 billion USD estimated at the end of 2023) to 2033 (679.03 billion USD expected by the end of 2033).

Ever since the advent of hybridoma technology introduced in 1975, antibody-based therapeutics have been realized using murine antibodies which further progressed into humanized and fully human antibodies, reducing the risk of immunogenicity.

Some benefits of using mAbs over conventional drugs include a drastic reduction in the chances of adverse reactions, interactions between drugs, and targeting specific proteins. While antibodies are very efficient, their higher production costs impede the process of commercialization.

However, their cost factor has been improved by developing biosimilar antibodies as affordable versions of therapeutic antibodies. The recent advancements and innovations in antibody engineering have helped and will further help to design bio-better antibodies with improved efficacy.

These novel mAb-based therapeutics are set to revolutionize existing drug therapies targeting a wide spectrum of diseases, thereby meeting several unmet medical needs.

More information: Hassan Aboul-Ella et al, Monoclonal antibodies: From magic bullet to precision weapon, Molecular Biomedicine (2024). DOI: 10.1186/s43556-024-00210-1