Products

DESCRIPTION

Basic Info

Model NO.	BS62556
Supply Type	OBM(Original Brand Manufacturing)
Usage Mode	For oral administration
Suitable for	Elderly, Adult
Type	Biological Diagnostic Reagents
Application	for Diagnosis, for Therapy, for Prevention
Form	Liquid
Specification	100ug/1mg
Trademark	Bioworld
Origin	China
Production Capacity	3000 Vials

Product Description

Catalog No.	BS62556
Product Name	ADAM10 polyclonal antibody
Applications	WB IHC
Alternative Name	RAK; kuz; AD10; AD18; MADM; CD156c; HsT18717
Swiss-Prot	O14672
Host	Rabbit
Reactivity	Human,Mouse,Rat
Application_all	WB: 1:500~1:1000 IHC: 1:50~1:200
Product	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity	ADAM10 polyclonal antibody detects endogenous levels of ADAM10 protein.
BiowMW	~ 90 kDa
Note	For research use only, not for use in diagnostic procedure.
Immunogen	Synthetic peptide, corresponding to Human ADAM10.

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  Western blot (WB) analysis of ADAM10 polyclonal antibody at 1:500 dilution LaneA:HepG2 whole cell lysate LaneB:U-87MG whole cell lysate LaneC:A549 whole cell lysate LaneD:SP2/0 whole cell lysate LaneE:PC12 whole cell lysate

Background

ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand) a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM10 is a TNF-processing enzyme that cleaves pro-TNF, a membrane-bound precusor protein, at Ala 76-Val 77, which causes membrane shedding of soluble TNF.