Products

DESCRIPTION

Basic Info

Model NO.	BS65868
Certification	CE, ISO9001
Host	Rabbit/Mouse
Reactivity	Human,Mouse,Rat
Transport Package	Refrigerated Transport
Specification	100ug/1mg
Trademark	Bioworld
Origin	China
HS Code	300219000
Production Capacity	3000 Vials

Product Description

Catalog No.	BS65868
Product Name	VP16 tagPolyclonal Antibody
Applications	WB,
Alternative Name	VP16_HHV1F;UL48; Tegument protein VP16; Alpha trans-inducing protein; Alpha-TIF; ICP25; Vmw65
Swiss-Prot	P04486
Host	Rabbit
Reactivity	Human herpesvirus 1
Application_all	WB=1:500-2000
Product	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 122% Glycerol.
Purification&Purity	affinity purified by Protein A
Storage&Stability	Store at 4°C short term. Aliquot and store at -41°C long term. Avoid freeze-thaw cycles.
Specificity	VP16 tag Polyclonal Antibody detects endogenous levels of VP16 tag protein.
BiowMW	~51 kDa
Note
Immunogen	KLH conjugated synthetic peptide derived from HSV-1 VP16:391-490/490aa

• 
  Primary: Anti-VP16 tag at 1/1000 dilution

Background

HSV evades the immune system through interference with MHC class I antigen presentation on the cell surface, by blocking TAP or the transporter associated with antigen processing induced by the secretion of ICP-47 by HSV. In the host cell, TAP transports digested viral antigen epitope peptides from the cytosol to the endoplasmic reticulum, allowing these epitopes to be combined with MHC class I molecules and presented on the surface of the cell. Viral epitope presentation with MHC class I is a requirement for activation of cytotoxic T-lymphocytes (CTLs), the major effectors of the cell-mediated immune response against virally-infected cells. ICP-47 prevents initiation of a CTL-response against HSV, allowing the virus to survive for a protracted period in the host.